In the era of artificial intelligence, what do we need to know about cancer? What have we been doing wrong and where do we still have to go? Manuel Sobrinho Simões is worried. It is the overdiagnosis and overtreatment of the disease that causes him the most distress, at a time when it is known that there are 3% more cases per year in Portugal, despite the disease becoming less and less lethal. At 76 years old, the “most influential pathologist in the world” continues to look passionately through the microscope, going every day to the institute he founded in Porto, and, even so, being afraid of the disease he studied his entire life